Registration form
To place an order or request a quote for Ipsogen products, please fill in the form below and click the Register button. Then you will be able to add products in your basket.
Fields preceded by an asterisk (*) are required.
Inquiry Type:	Order Request a quote
Order/Request date:
First name (*) :
Last name (*) :
Company or Institution (*) :
Country (*) :	Select your country ... Åland Islands Afghanistan Albania Algeria American Samoa Andorra Angola Anguilla Antarctica Antigua and Barbuda Argentina Armenia Aruba Australia Austria Azerbaijan Bahrain Bangladesh Barbados Belarus Belgium Belize Benin Bermuda Bhutan Bolivia Bosnia and Herzegovina Botswana Bouvet Island Brazil British Indian Ocean Territory British Virgin Islands Brunei Bulgaria Burkina Faso Burundi Côte d’Ivoire Cambodia Cameroon Canada Cape Verde Cayman Islands Central African Republic Chad Chile China Christmas Island Cocos (Keeling) Islands Colombia Comoros Congo Congo-Brazzaville Cook Islands Costa Rica Croatia Cuba Cyprus Czech Republic Denmark Djibouti Dominica Dominican Republic Ecuador Egypt El Salvador Equatorial Guinea Eritrea Estonia Ethiopia Falkland Islands Faroes Fiji Finland France French Guiana French Polynesia French Southern Territories Gabon Gambia Georgia Germany Ghana Gibraltar Greece Greenland Grenada Guadeloupe Guam Guatemala Guinea Guinea-Bissau Guyana Haiti Heard Island and McDonald Islands Honduras Hong Kong SAR of China Hungary Iceland India Indonesia Iran Iraq Ireland Israel Italy Jamaica Japan Jordan Kazakhstan Kenya Kiribati Kuwait Kyrgyzstan Laos Latvia Lebanon Lesotho Liberia Libya Liechtenstein Lithuania Luxembourg Macao SAR of China Macedonia Madagascar Malawi Malaysia Maldives Mali Malta Marshall Islands Martinique Mauritania Mauritius Mayotte Mexico Micronesia Moldova Monaco Mongolia Montenegro Montserrat Morocco Mozambique Myanmar Namibia Nauru Nepal Netherlands Netherlands Antilles New Caledonia New Zealand Nicaragua Niger Nigeria Niue Norfolk Island North Korea Northern Marianas Norway Oman Pakistan Palau Palestine Panama Papua New Guinea Paraguay Peru Philippines Pitcairn Islands Poland Portugal Puerto Rico Qatar Reunion Romania Russia Rwanda São Tomé e Príncipe Saint Helena Saint Kitts and Nevis Saint Lucia Saint Pierre and Miquelon Saint Vincent and the Grenadines Samoa San Marino Saudi Arabia Senegal Serbia Seychelles Sierra Leone Singapore Slovakia Slovenia Solomon Islands Somalia South Africa South Georgia and the South Sandwich Islands South Korea Spain Sri Lanka Sudan Suriname Svalbard Swaziland Sweden Switzerland Syria Taiwan Tajikistan Tanzania Thailand The Bahamas Timor-Leste Togo Tokelau Tonga Trinidad and Tobago Tunisia Turkey Turkmenistan Turks and Caicos Islands Tuvalu Uganda Ukraine United Arab Emirates United Kingdom United States United States Minor Outlying Islands Uruguay US Virgin Islands Uzbekistan Vanuatu Vatican City Venezuela Vietnam Wallis and Futuna Western Sahara Yemen Zambia Zimbabwe
Valid email (*) :
Email confirmation (*) :
Tel:
Fax:
Purchase order # (if you already have one)
Quote # (if you already have one)
Discount # (if you already have one)
Delivery address (*) :
Billing address: (if different)

The BCR-ABL fusion gene is associated with formation of the Philadelphia chromosome (Ph) and is one of the most common genetic abnormalities detected in leukemia.
The Ph chromosome is found In more than 95% of Chronic Myeloid Leukemia (CML) cases and is the hallmark of this disease. In addition, in Acute Lymphoblastic Leukemia (ALL), Ph is detected in 20-40% of adult and 2-5% of childhood cases.

At the molecular level, the Ph chromosome or t(9;22) results in the juxtaposition of the 5' part of the BCR gene (chromosome 22) to the 3' part of the ABL gene (chromosome 9).

In the vast majority of patients, the breakpoints in the BCR gene are clustered within three well defined regions:

• Minor breakpoint cluster region (mbcr): corresponding to BCR gene (e1) juxtaposed to these condexon of the ABL gene exon (a2).
• Major breakpoint cluster region (Mbcr): corresponding to BCR gene exon (b3) or (b2) juxtaposed to these condexon of the ABL gene exon (a2) and the fusion transcripts (b3-a2 and b2-a2, respectively).
• Micro breakpoint cluster region (µbcr): very rare.

Therapy of Ph+ patients has been revolutionized by the introduction of tyrosine kinase inhibitors. Since the frequency of cytogenetic response is now very high, it is necessary to measure the level of BCR-ABL transcripts to determine MRD.

See relevant publications

Ipsogen FusionQuant® kits are unique molecular kits providing standardization and accurate quantification of fusion gene transcripts in leukemia.

FusionQuant® kit key points

• Sensitive and quantitative measurement of the fusion transcript
• Determination of the expression level of the fusion transcript relative to the ABL, GUS or BCR control genes
• Facilities and QMS compliant with ISO 13485 : 2003
• Multi-instrument compatibility
• Ready to use pre-diluted solutions
• Reduced risk of contamination
• Validated standards for the specific fusion and control gene
• EAC Standardized RQ-PCR procedures

Ipsogen BCR-ABL Mbcr / ABL FusionQuant® Kits are unique molecular kits providing standardization and accurate quantification of fusion gene transcripts in leukemia.

BCR-ABL Mbcr / ABL FusionQuant® Kit key points

Clinical advantages

• Sensitive follow-up of Minimal Residual Disease in patients under Imatinib (Gleevec®)
• Standardized technology validated by a multicentric study (EAC network)
• Ready-to-Use CE marked kits for In Vitro Diagnostic
• Clinical significance demonstrated and validated by leading institutions

Laboratory advantages

• Use peripheral blood specimen instead of bone marrow
• Quick test less than 3-hour turn-around time
• Reduced risk of contamination
• Sensitive quantitative measurement of BCR-ABL Mbcr
• Available: Cell Lines (Positive, Low and Negative controls for BCR-ABL Mbcr) used as Qualitative Control of total RNA extraction, reverse transcription and amplification steps for the RQ-PCR analysis

Description & performances

• 24 to 30 patient samples in duplicate
• Results in normalized copy numbers (NCN)
• Facilities and QMS compliant with ISO 13485 : 2003
• Multiplatform compatibility
• Sensitivity in Normalized Copy Number: 0.084
  
  
  

Main Products
Biomarker	Product	Indication(s)	Content	Product description	Instructions for use	Material Safety Data Sheet	Product reference	Add to basket
BCR-ABL Mbcr / ABL	BCR-ABL Mbcr / ABL FusionQuant®Kit	Monitoring	24-30 samples in duplicate				FQPP-10-ABL
BCR-ABL Mbcr / BCR	FusionQuant®Kit	Monitoring	24-30 samples in duplicate				FQPP-10-BCR
BCR-ABL Mbcr / GUS	FusionQuant®Kit	Monitoring	24-30 samples in duplicate				FQPP-10-GUS
BCR-ABL Mbcr / ABL	FusionQuant® Mega Kit	Monitoring	52-64 samples in duplicate				FQPP-10M-ABL
BCR-ABL Mbcr / BCR	FusionQuant® Mega Kit	Monitoring	52-64 samples in duplicate				FQPP-10M-BCR
BCR-ABL Mbcr / GUS	FusionQuant® Mega Kit	Monitoring	52-64 samples in duplicate				FQPP-10M-GUS
Associated Products
Biomarker	Product	Indication(s)	Content	Product description	Instructions for use	Material Safety Data Sheet	Product reference	Add to basket
RT complete set	Reverse Transcription Kit	Monitoring	33 reactions				RT-01
BCR-ABL Mbcr Control Kit	Control Cell Lines (RUO product)	Monitoring	1 reaction				CLCK-01
BCR-ABL mbcr Control Kit	Control Cell Lines (RUO product)	Monitoring	1 reaction				CLCK-02
High BCR-ABL Mbcr Positive Control	Control Cell Lines (RUO product)	Monitoring	1 reaction				PCCL-01
High BCR-ABL mbcr	Control Cell Lines (RUO product)	Monitoring	1 reaction				PCCL-02
Low BCR-ABL Mbcr Positive Control	Control Cell Lines (RUO product)	Monitoring	1 reaction				PCCL-03
Low BCR-ABL mbcr Positive Control	Control Cell Lines (RUO product)	Monitoring	1 reaction				PCCL-04
Negative BCR-ABL Mbcr & mbcr	Control Cell Lines (RUO product)	Monitoring	1 reaction				PCCL-05
BCR-ABL Mbcr Fusion Gene Standard	FusionQuant® Standards	Monitoring	4 reactions in duplicate				FGRS-10
ABL Control Gene	FusionQuant® CG Standards		4 reactions in duplicate				CGRS-01
B2M Control Gene	FusionQuant® CG Standards		4 reactions in duplicate				CGRS-02
GUS Control Gene	FusionQuant® CG Standards		4 reactions in duplicate				CGRS-03
TBP Control Gene	FusionQuant® CG Standards		4 reactions in duplicate				CGRS-04
BCR Control Gene	FusionQuant® CG Standards		4 reactions in duplicate				CGRS-05