MLL translocations

• About this biomarker
• Introduction to our products
• Why choose our products
• Main products for MLL translocations
• Associated products
• Related publications

Reciprocal rearrangements of the MLL gene are among the most common chromosomal abnormalities in both Acute Lymphoblastic and Myeloid Leukemia.

The MLL gene, located on the 11q23 chromosomal band, is involved in a large number of different chromosomal translocations resulting in a range of MLL fusion proteins.

These different types of translocations tend to be associated with a specific type of leukemia.

For example, the t(9;11) translocation of the MLL and AF9 genes is mainly found in acute myeloid leukemia while the t(11;4) translocation of the MLL and AF4 genes is found in Acute lymphoblastic leukemia.

MLL translocations FusionQuant® technology uses Real-Time Quantitative RQ-PCR to quantify the expression level of specific MLL translocations.

Why choose MLL translocations FusionQuant® Standards?

• EAC Standardized RQ-PCR procedures

• Compatibility with most RQ-PCR platforms

• Calibrated and sensitive quantification of fusion gene transcript, normalized with ABL (BCR or GUS) control gene (results in NCN)

• Ready-to-Use plasmid standards

Standardization and quality control studies of 'real-time' quantitative reverse transcriptase polymerase chain reaction of fusion gene transcripts for residual disease detection in leukemia - a Europe Against Cancer program.
Leukemia. 2003
Authors: Gabert J et al.

Evaluation of candidate control genes for diagnosis and residual disease detection in leukemic patients using 'real-time' quantitative reverse-transcriptase polymerase chain reaction (RQ-PCR) - a Europe against cancer program.
Leukemia. 2003
Authors: Beillard E et al.